Couple of things.....
If its within shotgun range....it's likely on a direct and fast flight path to bop you in the head and/or explode. Best of luck with your reaction times and lets hope it has a poor CEP.
Within shotgun range and loitering? Unless you are a good looking female, very little reason for one to be that close to you.
At anything beyond 40ish yards/shotgun range, which is more likely, many times over shotgun range, you now have the problem of estimating range, and then the unfortunate effects of gravity on high inclination shots making you go grey. Even if the operator was kind enough to hover in place for you, and you weren't under fire/needing to scoot between volleys, trying to get the range, then sit down with your ballistics calculator to work out the math, and finding a buddy who won't complain over you using his shoulder as a human bipod/biped ("quit moaning about yer ears Bubba, you are messing up my aim!), the shot is still going to involve a LOT of luck.
I happened to once know guy who in his youth, used to go out to a desolate trash dump on the weekends with a buddy. The sky over the dump often had turkey vultures blackening the sky. The estimated range was often in the 500 yard range. A Mini-14 and a Schmitt Rubin K-31 fired for effect over and over with no obvious success. That I would presume to be a likely drone range. 100's of targets, bunched together, shots bracketed, no success.
The best I ever saw was a buddy with a 12 ga and 00 buck had a turkey vulture who ventured too close, about 60 yards, stuck in high winds making no headway, at about a 75 degree angle, start flapping at 2 or 3 out of 7 or 8 shots, indicating some sort of effect, who eventually flew off apparently unharmed.
That incident alone doesn't give me much reason for hope using small arms fire.