Mt 11:28 venite ad me omnes qui laboratis et onerati estis et ego reficiam vos
The latin onero brings out the physicality of the term: a load, a weight, a freight or as in English "burden" as in "beast of burden." This verse, I think, fits well not only with in-the-moment trials and tribulations, but also very much end-of-life weariness and struggle.
Also, the latin recifio implies not simply "rest," but to be renewed, "put into working condition again," restored.
So one expansive translation of this might be: Come to me all you who are worn down and hurting (from trials & labors in this Vale of Tears) and I shall render you whole and renewed.
fwiw