From The Primer on Primers I posted at the top of this section...
Remington 6 ½ - thin .020" cup, intended for older, lower pressure rounds Remington says do not use for the .223 Rem or other similar pressure rounds. Good for .22 Hornet, .30 Carbine.
Should be able to use them for small pistol if the firing pin strike is sufficient. Small rifle and small pistol are the same size. Brisance might be closer to small pistol magnum.
From Part 2 of The Primer on Primers above...
This also affects pressure tolerance. Cases that utilize small rifle primers and operate at moderate pressures(40,000 psi) should use CCI 400, Federal 200, Rem 6 1/2, or Win WSR. Such cases include 22 CCM, 22 Hornet and the 218 Bee. These primers can also used in handguns such as the 9mm., 357, etc. Other cases that use the small rifle primer can use the above primers only if moderate loads are used. Keep to the lower end of reloading recommendations.