Genetic testing for gene mutations and supplementation, anyone done it?

chiefjason

chiefjason

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So we listened to Gary Brecka on Joe Rogan the other day. He was talking about gene testing for mutations and supplementing for those mutations. I'll link the podcast at the bottom. Considered getting tested through his 10X. Dug around a bit and found another option. You can download your Ancestry or 23andme raw DNA data and Nutrahacker will test that info for free. Since genetic info does not change, and free is good, I did it.

Welcome to NutraHacker! Upload raw DNA data from Nebula, Sequencing, DanteLabs, WeGene, 23andMe, AncestryDNA, tellmeGen, MyHeritage, GenomeItAll, MyHappyGenes, LifeDNA or FitnessGenes for DNA raw data analysis

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Well, I've apparently got enough gene mutations I might grow up to be an X man. The reading of my info indicated 17 gene mutations. Along with the indications you get gene function run down, consequences of the mutation, some do's and don'ts, and suggested supplements as well as those to avoid. FYI, the initial information is only available for a short time. So download and print it immediately. Otherwise I think you have to buy your way back into it.

So I'm going to tweak what I'm doing supplement wise to get it in line with these issues and see how that works. I've got issues with MTHFR, MTR, MTRR, and VDR and a couple lesser ones. This means issues with folic acid, b12s, homocysteine, and others that my body struggles to or does not process. You can further dig into how to supplement for those, good and bad foods, etc. You are looking to supplement for the compounds that your gene mutation does not allow your body to produce.

So if you have any issues that medication does not fix, this might be a route to try. Cholesterol, BP, chronic fatigue, lots of gut issues, tinnitus, depression, ADHD, liver function, and many more. And I've never been able to budge my cholestorol with diet or meds, and my BP is all over the place. Unless I stay on top of it. If not, it skyrockets.

So far I've changed my multi vitamin to a methylated version, have TMG powder on order, NCA, and Quercitin. I'm ditching my current multi vitamin powder, AG1.

So, off we go. Let's see what this does.


 
Chuckman said:
That's a knife that cuts both ways. If DNA shows scary stuff, they may be induced to cut coverage.
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Since the ACA was enacted in 2013 (i.e. Obamacare) it’s my understanding that medical underwriting by the insurance companies (aka "pre-existing conditions") is no longer a legal consideration, although I personally would be also scared to open that Pandora’s box.
 
Folks, go watch the movie Gattaga, That will throw some cold water on the idea of having your genetic information floating out there.

I have a double copy of the recessive factor V mutation which makes me more susceptible to blood clots and take warfarin. My pharmacist called one day and said Duke is doing a research study to test genetic conditions related to how you absorb and process a few drugs, including warfarin and asked if I were interested. I was and got $50:for participating and learned I have normal warfarin metabolism.

However, that’s now twice that some sort of DNA sequencing was run in me and those results may be .. where ??
 
noway2 said:
Folks, go watch the movie Gattaga, That will throw some cold water on the idea of having your genetic information floating out there.

I have a double copy of the recessive factor V mutation which makes me more susceptible to blood clots and take warfarin. My pharmacist called one day and said Duke is doing a research study to test genetic conditions related to how you absorb and process a few drugs, including warfarin and asked if I were interested. I was and got $50:for participating and learned I have normal warfarin metabolism.

However, that’s now twice that some sort of DNA sequencing was run in me and those results may be .. where ??
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I have lots of thoughts and opinions on this, but admittedly am not well versed or smart enough to say something coherent. I have doubts about what the current science claims it can do and knows, and doubts about how the information may be used.

I am sticking with the attempt to be well balanced in my diet and exercise. And to avoid as much lab created nonsense as I can. Beyond that I have zero certainties.
 
CZfool68 said:
I have lots of thoughts and opinions on this, but admittedly am not well versed or smart enough to say something coherent. I have doubts about what the current science claims it can do and knows, and doubts about how the information may be used.

I am sticking with the attempt to be well balanced in my diet and exercise. And to avoid as much lab created nonsense as I can. Beyond that I have zero certainties.
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I’m skeptical with background in biology, genetics and nutrition, but always want to see raw resulting data on new technologies and claims. I want to see the numbers and other factors. Factors such as, by spending the money doing this, is a person more critical of their everyday activities and health in general? Is the specific information they gained actually making improvements or are they just more health conscious to justify the spending?
 
Jimbob78 said:
I’m skeptical with background in biology, genetics and nutrition, but always want to see raw resulting data on new technologies and claims. I want to see the numbers and other factors. Factors such as, by spending the money doing this, is a person more critical of their everyday activities and health in general? Is the specific information they gained actually making improvements or are they just more health conscious to justify the spending?
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Good on you. I know some people with Master’s degrees, PHD’s and such things that are so smart they refuse to think they could ever be wrong or misinformed about anything. Ego is an SOB sometimes.
 
CZfool68 said:
Good on you. I know some people with Master’s degrees, PHD’s and such things that are so smart they refuse to think they could ever be wrong or misinformed about anything. Ego is an SOB sometimes.
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It could very well be a game changer in health, which would be quite fascinating and with my grad school in nutrition, it would very intriguing learning how a specific gene expression plays a role in the regulation of nutrient uptake and utilization. This would go beyond just human health and performance but could be explored in animal athletes to increase performance and breeding.
 
Jimbob78 said:
It could very well be a game changer in health, which would be quite fascinating and with my grad school in nutrition, it would very intriguing learning how a specific gene expression plays a role in the regulation of nutrient uptake and utilization. This would go beyond just human health and performance but could be explored in animal athletes to increase performance and breeding.
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What if the currently understanding of genetics is total BS? Then all of these things are BS right?
 
CZfool68 said:
What if the currently understanding of genetics is total BS? Then all of these things are BS right?
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Could very well be. I have no doubt that there is an understanding of genetics, horticultural genetics is a prime example. When I breed dogs, color gene work is pretty solid; I know what colors to expect based on genotype of the parents. Is there a lot to genetics that is unknown: absolutely, and it’s exciting to see where it’s headed. As stated, I’m skeptical of the bold claims from this program, but intrigued to see the actual raw data.
 
Howland said:
They are. Why else would genetic testing be free? It's actually fairly expensive.
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The "free" on this one is just reading the data. The DNA testing certainly was not free. Although not terribly expensive either. Ancestry is $99 when it's not on sale. It's $39 for a few more days on sale.

Some of the dedicated medical DNA testing with read is $500-800 dollars. That is what has kept me out of that process.

We will see how this goes. Although the last couple days I have been doing a few of the things and really do notice I feel better and seem to have more energy/less tired. The sun exposure, grounding (bare feet on dirt), and breath work is all free and certainly can help you feel better.

@Jimbob78 If you have social media look up Dana White from UFC. He did the full 10 week program with Brecka, and they go into that on Rogan. Dana has been posting a lot of his actual blood work online to prove what it has done for him. Brecka also has an interview with Dana on his podcast. Not sure if it will have the info you want or not. But apparently he gives up everything he has in some of his posts.

Could be crap. But at least with Dana, he had drastic health changes based on this stuff. I already try to eat well, exercise, and generally try to stay in good shape. But a few years back I lost 49 lbs and was working out almost every day. My BP changed for the better. But my Cholesterol did not even budge. I can shift some of what I spend on other things into this and probably even save some money doing this. So it's worth a shot to see if it helps.
 
As I've said on here before I have done my DNA for genealogy, besides we had it in the military, too. At this point It is what it is.

And I know with 100 percent certitude that DNA testing is extremely valuable for testing for latent disease. Some diseases are just genetic. Could it be used to assess factors for nutritional growth and help you tailor-make supplementation? Yeah, I suppose so.

All that said, I'm just increasingly dubious of the proliferation of DNA in the digital space and who can use it for what (or, who will use it without you knowing about it).
 
chiefjason said:
Well, I've apparently got enough gene mutations I might grow up to be an X man. The reading of my info indicated 17 gene mutations. Along with the indications you get gene function run down, consequences of the mutation, some do's and don'ts, and suggested supplements as well as those to avoid. FYI, the initial information is only available for a short time. So download and print it immediately. Otherwise I think you have to buy your way back into it.
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Splitting hairs here, but "polymorphism" is often the preferred word over mutation.
People are different, and stuff acts differently on different people. So while whatever it was originated as a mutation, it wasn't "bad" or "bad enough" to keep that genetic lineage from continuing to spread.

Wife did one of these a long time ago. Some of it was pretty accurate, some of it made no sense. Still not a bad idea though if it's something you need. Privacy is becoming an issue, more from big companies than small research things. Ask me where any of my research data is. I'll point to an external drive on my shelf. I have seen entire rooms filled with obscure data that nobody will ever look at again, but you still gotta keep a copy somewhere...
 
DrScaryGuy said:
Splitting hairs here, but "polymorphism" is often the preferred word over mutation.
People are different, and stuff acts differently on different people. So while whatever it was originated as a mutation, it wasn't "bad" or "bad enough" to keep that genetic lineage from continuing to spread.

Wife did one of these a long time ago. Some of it was pretty accurate, some of it made no sense. Still not a bad idea though if it's something you need. Privacy is becoming an issue, more from big companies than small research things. Ask me where any of my research data is. I'll point to an external drive on my shelf. I have seen entire rooms filled with obscure data that nobody will ever look at again, but you still gotta keep a copy somewhere...
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Back off! I identify as a mutant now! lol
 
So I can send something from Ancestry to someone else and they can tell me I'm gonna die of everything? Perfect. Now to figure out the how.
 
DrScaryGuy said:
. Ask me where any of my research data is. I'll point to an external drive on my shelf. I have seen entire rooms filled with obscure data that nobody will ever look at again, but you still gotta keep a copy somewhere...
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Researcher = Hoarder 😁

In my business, I have seen the dark side of "must keep data/samples/tissue/etc..". I have to do an intervention or two also. It gets real interesting when the PI/project left 10 years ago but the stuff is still around.
 
CZfool68 said:
Sounds like one of the boys made a nice catch. Well played.
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She’s dual citizen Swiss/Gringo.

She loves her Swiss grandma. Might have to buy plane tickets for a wedding.
 
cold1 said:
Researcher = Hoarder 😁

In my business, I have seen the dark side of "must keep data/samples/tissue/etc..". I have to do an intervention or two also. It gets real interesting when the PI/project left 10 years ago but the stuff is still around.
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well, some if it is subject to FOIA and what not if it's NIH/FDA/ETC funded, so you are literally mandated to keep copies.
but yeah, nobody knows what's crammed in the back of the bottom shelf of the -40 freezers.
 
fieldgrade said:
She’s dual citizen Swiss/Gringo.

She loves her Swiss grandma. Might have to buy plane tickets for a wedding.
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Livestream. All the kids do it these days.

CZfool68 said:
My theory has always been bribery and elopement. It might get me killed by the Moms, but I’m going to take that risk. I f’ing hate weddings.
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Yes. A million times yes. A check for $5,000 and a restraining order.
 
noway2 said:
That was Egon and you encountered his collection of spores, molds, and fungus.
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Nothing like popping the top on a -80 chest freezer and having frozen faces looking back at you in the Brinkhous building.
 
If you get these DNA tests things done for free how do you think these companies make their money back?
 
Bigdave0924 said:
If you get these DNA tests things done for free how do you think these companies make their money back?
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Same way the ones you pay for make extra money? 🤷‍♂️

According to my wife there was no information outside the raw data associated with submitting it. Not that you could not dig enough to figure it out via email. But let’s be honest. No one is hiding anymore. If you think you are, you are probably wrong.

It’s on the short side right now. But there seem to be some positive effects of what I’m doing because of the testing. Gonna take more time to feel like it’s positively connected.
 
noway2 said:
I knew the used to have the morgue there. It creeped the I&C guys out.
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The morgue at Chapel Hill? Ironic that the morgue also had the best view in Chapel Hill. That place was always super busy during the day, but creepy AF in the middle of the night when no one was there.
 
Dale Gribble said:
Had genetic testing done after the cancer diagnosis…primarily for my kids benefit.
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Wish I had known and done this. I was diagnosed with cancer, survived thus far. My son was diagnosed with the same cancer while he was in the Air Force during pilot training. I had no idea our type of cancer had a genetic component. Fortunately we had discussed my situation in the past so when he started having symptoms he knew not to wait and go see the doc.
 
Chuckman said:
The morgue at Chapel Hill? Ironic that the morgue also had the best view in Chapel Hill. That place was always super busy during the day, but creepy AF in the middle of the night when no one was there.
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I’ve often stared out of the windows there and wondered how something so beautiful could be so close to something so horrible (mine were all homicides).
 
Average Joe said:
I’ve often stared out of the windows there and wondered how something so beautiful could be so close to something so horrible (mine were all homicides).
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For a while in EMS we had to transport all the ME bodies, the traumas, as well as medical. We ended up contracting that out to a different service. Definitely a weird vibe.
 
Average Joe said:
I’ve often stared out of the windows there and wondered how something so beautiful could be so close to something so horrible (mine were all homicides).
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I stayed on the hospital side. I had to go in the State ME side a few times, It's definitely different on that side. I avoided it when I could.
 
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